A new study published in Nature Communications has shed light on how cannabis use may affect women undergoing IVF, with findings that fertility specialists say warrant serious attention.
The research analysed more than 1,000 follicular fluid samples from IVF patients, finding that those with detectable levels of THC (the psychoactive compound in cannabis) around the time of egg collection showed a faster rate of egg maturation and a lower proportion of chromosomally normal embryos compared to a matched control group. Separate laboratory analysis found that exposing immature eggs to THC levels consistent with those observed in the study produced higher rates of chromosomal errors.
Clinical Associate Professor Alex Polyakov, Medical Director of Genea Fertility Melbourne, said the results indicated that cannabis use may compromise reproductive outcomes not by preventing fertilisation, but by reducing the likelihood of producing chromosomally normal embryos. Because embryo chromosomal normality is closely linked to successful implantation and healthy pregnancy, he noted that cannabis exposure could prolong the time to conception and increase the risk of IVF failure and miscarriage.
Assoc Prof Polyakov called for fertility specialists to routinely and non-judgmentally ask patients about cannabis use, given it is often under-reported. His advice is clear: patients should avoid cannabis while attempting conception or undergoing IVF, as even occasional use may expose eggs to THC.
Researchers acknowledge that larger studies are needed to better understand dose and frequency effects, and whether the risks extend to natural conception. Read the full article for the complete findings and expert commentary.
A/Prof Alex Polyakov
Associate Professor Alex Polyakov is an Obstetrician, Gynaecologist and Fertility specialist practicing in East Melbourne. A/Prof Polyakov is unique among fertility specialists by offering a holistic approach that encompasses surgical, fertility, and obstetric care. This means Alex is highly trained to perform surgical interventions for gynaecological conditions such as fibroids, endometriosis, and intrauterine polyps/adhesions.
